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KMID : 1123920030170020568
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 2 p.568 ~ p.573
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Effect of the Geijibokryunghwan on human hepatocarcinoma cells
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Lee Soo-Kyung
Kim Han-Geu
Ahan Jong-Chan
Chung Tae-Wook
Moon Jin-Young
Park Sun-Dong
Kim June-Ki
Choi Dall-Yeong
Kim Cherl-Ho
Park Won-Hwan
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Abstract
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We invesgated the GBH water extracts can be used as a potential cancer chemopreventive agent in humans, especially in hepatological cancer cell lines. The GBH was found to act as an potent inhibitor of COX-I only, but not as COX-2 inhibitor. Furthermore, the extract mediated anti-inflammatory effects and inhibited COX-associated hydroperoxidase functions(antipromotion activity). Inhibitory effect of the GBH water extracts on the growth of cancer cell lines such as HepG2 cell and Hep3B cell was shown.
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KEYWORD
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Geijibokryunghwan, hepatocarcinoma chemoprevention cyclooxygenase (COX)
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